Roche, Richard and Hogan, Michael and Carolan, Leigh and Dockree, Paul and Kaiser, Jochen and Bunting, Brendan and Robertson, Ian and Lawlor, Brian (2006) Electrophysiological and information processing variability predicts memory decrements associated with normal age-related cognitive decline and Alzheimer's disease (AD). Brain Research, 1119 (1). pp. 215-226.

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Abstract

Recent theoretical models of cognitive aging have implicated increased intra-individual variability as a critical marker of decline. The current study examined electrophysiological and information processing variability and memory performance in normal younger and older controls, and older adults with Alzheimer's disease (AD). It was hypothesized that higher levels of variability would be indicative of age-related and disease-related memory deficits. Results indicated both implicit and explicit memory deficits associated with AD. Consistent with previous research, behavioral speed and variability emerged as sensitive to age- and disease-related change. Amplitude variability of P3 event-related potentials was a unique component of electrophysiological activity and accounted for significant variance in reaction time (RT) mean and RT standard deviation, which in turn accounted for significant variance in memory function. Results are discussed in light of theoretical and applied issues in the field of cognitive aging.

Item Type:	Article
Keywords:	Event-related potential; Variability; Alzheimer's; Aging; Memory;
Academic Unit:	Faculty of Science and Engineering > Psychology
Item ID:	1011
Depositing User:	Richard Roche
Date Deposited:	26 May 2008
Journal or Publication Title:	Brain Research
Publisher:	Elsevier
Refereed:	Yes
URI:	http://www.sciencedirect.com/science/jou...
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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