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An in-silico analysis of the SMART study of HIV infection

Ferreira, Jorge and Middleton, Rick (2008) An in-silico analysis of the SMART study of HIV infection. IFAC Symposia Series.

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Abstract

A mathematical model is developed to further examine the dynamic interaction of uninfected T cells with Human Immunodeficiency Virus (HIV) mutations. We study how the dynamics are affected by immune response to infected cells under intermittent antiretroviral therapy. Our goal is to analyze the SMART (Strategies for Management of anti-retroviral Therapy) study outcomes and based on that try to identify possible causes of its failure. We mathematically describe the HIV infection and perform numerical simulation to approach the course of the disease. Preliminary results suggest that the scheduling of follow-up visits and working range of CD4+ T cells count used during the SMART study could explain the observed adverse outcomes in that trial.

Item Type: Article
Keywords: Modelling and simulation; Biomedical systems; Control theory; HIV dynamics; In-Silico; Hamilton Institute.
Subjects: Science & Engineering > Biology
Science & Engineering > Hamilton Institute
Item ID: 1660
Depositing User: Hamilton Editor
Date Deposited: 16 Nov 2009 14:50
Journal or Publication Title: IFAC Symposia Series
Publisher: Pergamon
Refereed: Yes
URI:

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