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The Virtual Lab Approach to Pharmacokinetics: Design Principles and Concepts.

Huisinga, Wilhelm and Telgmann, Regina and Wulkow, Michael (2006) The Virtual Lab Approach to Pharmacokinetics: Design Principles and Concepts. Drugs Discovery Today, 11 (17-18). pp. 773-862. ISSN 1359-6446

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Abstract

Modeling and simulation in pharmacokinetics has has turned into the focus of pharmaceutical companies, driven by the emerging consensus that in silico predictions combined with in vitro data have the potential of significantly increasing insight into pharmacokinetic processes. To adequately support in silico methodology, software tools need to be user-friendly and, at the same time, flexible. In brief, the software has to allow the realization of modeling ideas that are beyond current knowledge – in the form of a virtual lab. We present and discuss the necessary design principles and concepts. These have been implemented in the software package MEDICI-PK to demonstrate its feasibility and advantages.

Item Type: Article
Keywords: Virtual lab; In silico drug discovery; PBPK; Systems biology; Disease modeling; Hamilton Institute.
Subjects: Science & Engineering > Hamilton Institute
Science & Engineering > Chemistry
Science & Engineering > Mathematics
Item ID: 1739
Identification Number: 10.1016/j.drudis.2006.07.001
Depositing User: Hamilton Editor
Date Deposited: 04 Jan 2010 16:46
Journal or Publication Title: Drugs Discovery Today
Publisher: Elsevier
Refereed: No
URI:

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