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Results Towards Identifiability Properties of Biochemical Reaction Networks.

Farina, Marcello and Findeisen, Rolf and Bullinger, Eric and Bittanti, Sergio and Allgöwer, Frank and Wellstead, Peter (2006) Results Towards Identifiability Properties of Biochemical Reaction Networks. In: 45th IEEE Conference on Decision & Control Manchester Grand Hyatt Hotel San Diego, CA, USA, December 13-15, 2006. IEEE, pp. 2104-2109. ISBN 1-4244-0171-2

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Abstract

In this paper we consider the question of parameter identifiability for biochemical reaction networks, as typically encountered in systems biology. Specifically, we are interested in deriving conditions on the biochemical reaction network and on the measured outputs that guarantee identifiability of the parameters. Taking the specific system structure of biochemical reaction networks into account, we derive sufficient conditions for local parameter identifiability based on a suitable system expansion which does not anymore directly depend on the parameters. Rather, as shown, the problem of identifiability can be recast as the question of observability of the (parameter free) expanded system. The conditions derived are exemplified considering a simple example.

Item Type: Book Section
Additional Information: "©2006 IEEE. Reprinted from the 45th IEEE Conference on Decision & Control Manchester Grand Hyatt Hotel San Diego, CA, USA, December 13-15, 2006. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE." http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=4177963&isnumber=4176993
Keywords: Biochemistry; Observability; Parameter estimation; Physiological models; Biochemical reaction networks; Expanded system observability; Parameter free system observability; Parameter identifiability; Systems biology; Chemical reaction networks; Identifiability; Parameter identification; Systems biology; CDC 2006Hamilton Institute.
Subjects: Science & Engineering > Biology
Science & Engineering > Hamilton Institute
Science & Engineering > Chemistry
Item ID: 1777
Identification Number: 10.1109/CDC.2006.376925
Depositing User: Hamilton Editor
Date Deposited: 12 Jan 2010 10:42
Publisher: IEEE
Refereed: Yes
URI:

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