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Internal Exposure of Children by Simulated Acute Inhalation of Volatile Organic Compounds: The Influence of Chemical Properties on the Child/Adult Concentration Ratio

Abraham, K. and Mielke, H. and Huisinga, W. and Gundert-Remy, U. (2005) Internal Exposure of Children by Simulated Acute Inhalation of Volatile Organic Compounds: The Influence of Chemical Properties on the Child/Adult Concentration Ratio. Basic & Clinical Pharmacology & Toxicology (BCPT), 96 (3). pp. 242-243. ISSN 1742-7843

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Official URL: http://www3.interscience.wiley.com/cgi-bin/fulltex...

Abstract

A specific exposure scenario, namely the accidental release of industrial chemicals leading to an airborne exposure over a wide range of concentrations, requires special consideration in the risk assessment including that of sensitive subpopulations. In this context, children may be at higher risk compared to adults due to possible higher external exposure (behaviour, physiology), different kinetics (both leading to higher internal exposure) and different dynamics. The scope of this paper is the quantification of the age-dependent differences in the kinetics of children occurring during inhalation of volatile organic compounds (VOCs).

Item Type: Article
Additional Information: The definitive version is available at http://www3.interscience.wiley.com/cgi-bin/fulltext/118719013/PDFSTART
Keywords: Children; Inhalation; Kinetics; Model; Risk assessment; Hamilton Institute.
Subjects: Science & Engineering > Biology
Science & Engineering > Hamilton Institute
Science & Engineering > Chemistry
Item ID: 1846
Identification Number: 10.1111/j.1742-7843.2005.pto960315.x
Depositing User: Hamilton Editor
Date Deposited: 15 Feb 2010 17:10
Journal or Publication Title: Basic & Clinical Pharmacology & Toxicology (BCPT)
Publisher: Wiley-Blackwell Publishing Ltd.
Refereed: No
URI:

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