Internal Exposure of Children by Simulated Acute Inhalation of Volatile Organic Compounds: The Influence of Chemical Properties on the Child/Adult Concentration RatioAbraham, K. and Mielke, H. and Huisinga, W. and Gundert-Remy, U. (2005) Internal Exposure of Children by Simulated Acute Inhalation of Volatile Organic Compounds: The Influence of Chemical Properties on the Child/Adult Concentration Ratio. Basic & Clinical Pharmacology & Toxicology (BCPT), 96 (3). pp. 242-243. ISSN 1742-7843
AbstractA specific exposure scenario, namely the accidental release of industrial chemicals leading to an airborne exposure over a wide range of concentrations, requires special consideration in the risk assessment including that of sensitive subpopulations. In this context, children may be at higher risk compared to adults due to possible higher external exposure (behaviour, physiology), different kinetics (both leading to higher internal exposure) and different dynamics. The scope of this paper is the quantification of the age-dependent differences in the kinetics of children occurring during inhalation of volatile organic compounds (VOCs).
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