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A 5-component model for salt-induced hypertension

McLoone, Violeta I. and Ringwood, John V. and Van Vliet, Bruce (2009) A 5-component model for salt-induced hypertension. 7th IFAC Symposium on Modelling and Control in Biomedical Systems, ISBN: 978-3-902661-49-4. pp. 175-180.

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Abstract

Salt-induced hypertension has been widely studied in rats, monkeys, chimpanzees and humans. Until recently, the multiple phases of this blood pressure increase to high salt intake had not been closely studied. This work builds upon a recent study, which developed a grey-box multicomponent model of salt-induced hypertension in the Dahl-S rat. The previous 3-component model has been extended here to include additional model dynamics to improve the model fit and add new important elements to the model response. The model was optimised using numerical techniques with experimental data from 4 different protocols with Dahl-S and hybrid rats. Results show a marked improvement over the previous model and confirm the merit of the 5-component model structure.

Item Type: Article
Keywords: hypertension; mathematical model; salt intake; multiple components; Dahl-S;
Subjects: Science & Engineering > Electronic Engineering
Item ID: 2128
Depositing User: Professor John Ringwood
Date Deposited: 22 Sep 2010 15:36
Journal or Publication Title: 7th IFAC Symposium on Modelling and Control in Biomedical Systems, ISBN: 978-3-902661-49-4
Publisher: International Federation of Automatic Control
Refereed: Yes
URI:

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