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Mathematical modelling of autophagy pathway.

Zebrowska, Magdalena (2010) Mathematical modelling of autophagy pathway. Masters thesis, National University of Ireland Maynooth.

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Abstract

A system modelling autophagy is a new area of research. Current understanding of each step in this biochemical pathway is limited. The study of this mechanism is interesting in several aspects: autophagy plays an important role in physiological cellular processes, is a survival mechanism under external stress and is also connected with cancer and neurodegenerative diseases [Cuervo, 2004; Kondo et al., 2005; Levine, 2007; Pan et al., 2008]. Autophagy is the pathway for degradation of redundant or faulty cell components. This important mechanism occurs in all eukaryotic cells as a part of cell’s everyday activities and plays an important role in cell growth and development (cellular differentiation, immunity, cellular homeostasis). This work proposes a simple mathematical model of autophagy pathway as a system with feedback, which controls the level of the total amino acid pool. Feedback comes from the amino acids which are produced during the autophagy mechanism which is induced as a result of starvation or rapamycin treatment.

Item Type: Thesis (Masters)
Keywords: Mathematical modelling; Autophagy pathway; Proteins; Biochemical pathway; Cell growth; Cell development; Amino acids;
Subjects: Science & Engineering > Hamilton Institute
Item ID: 2653
Depositing User: IR eTheses
Date Deposited: 24 Aug 2011 17:25
URI:

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