Maynooth University

Maynooth University ePrints and eTheses Archive

Maynooth University Library

Mathematical modelling of autophagy pathway.

Zebrowska, Magdalena (2010) Mathematical modelling of autophagy pathway. Masters thesis, National University of Ireland Maynooth.

[img] Download (2MB)

Abstract

A system modelling autophagy is a new area of research. Current understanding of each step in this biochemical pathway is limited. The study of this mechanism is interesting in several aspects: autophagy plays an important role in physiological cellular processes, is a survival mechanism under external stress and is also connected with cancer and neurodegenerative diseases [Cuervo, 2004; Kondo et al., 2005; Levine, 2007; Pan et al., 2008]. Autophagy is the pathway for degradation of redundant or faulty cell components. This important mechanism occurs in all eukaryotic cells as a part of cell’s everyday activities and plays an important role in cell growth and development (cellular differentiation, immunity, cellular homeostasis). This work proposes a simple mathematical model of autophagy pathway as a system with feedback, which controls the level of the total amino acid pool. Feedback comes from the amino acids which are produced during the autophagy mechanism which is induced as a result of starvation or rapamycin treatment.

Item Type: Thesis (Masters)
Keywords: Mathematical modelling; Autophagy pathway; Proteins; Biochemical pathway; Cell growth; Cell development; Amino acids;
Subjects: Science & Engineering > Hamilton Institute
Item ID: 2653
Depositing User: IR eTheses
Date Deposited: 24 Aug 2011 17:25
URI:

    Repository Staff Only(login required)

    View Item Item control page

    Document Downloads

    More statistics for this item...