Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation
Singh, Ishwar and Vyle, Joseph S. and Heaney, Frances (2009) Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation. Chemical Communications (22). pp. 3276-3278. ISSN 1359-7345 AbstractSolid-phase oligonucleotide conjugation by nitrile oxide–alkyne
click cycloaddition chemistry has been successfully demonstrated;
the reaction, compatible with all nucleobases, requires
no metal catalyst and proceeds under physiological conditions. | Additional Information: | © Royal Society of Chemistry 2009 |
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| Keywords: | copper-free click chemistry; solid-phase; oligonucleotide conjugation; catalyst; |
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| Subjects: | Science & Engineering > Chemistry |
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| ID Code: | 2706 |
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| Deposited By: | Dr. Frances Heaney |
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| Deposited On: | 14 Sep 2011 14:53 |
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| Journal or Publication Title: | Chemical Communications |
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| Publisher: | Royal Society of Chemstry |
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| Refereed: | Yes |
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| URL: | http://pubs.rsc.org/ |
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