Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation
Singh, Ishwar and Vyle, Joseph S. and Heaney, Frances (2009) Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation. Chemical Communications (22). pp. 3276-3278. ISSN 1359-7345
Solid-phase oligonucleotide conjugation by nitrile oxide–alkyne click cycloaddition chemistry has been successfully demonstrated; the reaction, compatible with all nucleobases, requires no metal catalyst and proceeds under physiological conditions.
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