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    Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation


    Singh, Ishwar and Vyle, Joseph S. and Heaney, Frances (2009) Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation. Chemical Communications (22). pp. 3276-3278. ISSN 1359-7345

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    Abstract

    Solid-phase oligonucleotide conjugation by nitrile oxide–alkyne click cycloaddition chemistry has been successfully demonstrated; the reaction, compatible with all nucleobases, requires no metal catalyst and proceeds under physiological conditions.

    Item Type: Article
    Additional Information: © Royal Society of Chemistry 2009
    Keywords: copper-free click chemistry; solid-phase; oligonucleotide conjugation; catalyst;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 2706
    Identification Number: https://doi.org/10.1039/B904185K
    Depositing User: Dr. Frances Heaney
    Date Deposited: 14 Sep 2011 13:53
    Journal or Publication Title: Chemical Communications
    Publisher: Royal Society of Chemstry
    Refereed: Yes
    URI:
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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