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Establishment of Functional B Cell Memory Against Parvovirus B19 Capsid Proteins May be Associated With Resolution of Persistent Infection

Corcoran, A. and Crowley, B. and Dewhurst, C. and Pizer, B.L. and Doyle, S. (2006) Establishment of Functional B Cell Memory Against Parvovirus B19 Capsid Proteins May be Associated With Resolution of Persistent Infection. Journal of Medical Virology, 78. pp. 125-128.

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Abstract

Parvovirus B19 (B19) infection can occur during acute lymphoblastic leukemia and persistent viral infection can occur despite intravenous immunoglobulin administration. Here, evidence is presented that resolution of persistent B19 infection in an acute lymphoblastic leukemia patient may be associated with the simultaneous strengthening of antigen-specific B cell memory against the B19 capsid protein VP2 and diminution in the memory response against the B19 non-structural protein 1 (NS1). Determination of antigen-specific B cell memory status may enhance the serological and molecular analyses of persistent B19 infection.

Item Type: Article
Keywords: ALL; immunocompromised; B cell ELISpot; leukemia; erythrovirus;
Subjects: Science & Engineering > Biology
Item ID: 296
Depositing User: Dr. Sean Doyle
Date Deposited: 08 Sep 2006
Journal or Publication Title: Journal of Medical Virology
Publisher: Wiley Liss, Inc.
Refereed: Yes
URI:

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