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CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease

Thome, J. and Coogan, Andrew and Woods, A.G. and Darie, C.C. and Habler, F. (2011) CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease. Journal of Aging Research. ISSN 2090-2204

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Abstract

Disturbed circadian rhythms with sleep problems and disrupted diurnal activity are often seen in patients suffering from Alzheimer disease (AD). Both endogenous CLOCK genes and external Zeitgeber are responsible for the maintenance of circadian rhythmicity in humans. Therefore, modifications of the internal CLOCK system and its interactions with exogenous factors might constitute the neurobiological basis for clinically observed disruptions in rhythmicity, which often have grave consequences for the quality of life of patients and their caregivers. Presently, more and more data are emerging demonstrating how alterations of the CLOCK gene system might contribute to the pathophysiology of AD and other forms of dementia. At the same time, the impact of neuropsychiatric medication on CLOCK gene expression is under investigation.

Item Type: Article
Keywords: CLOCK Genes; Circadian Rhythmicity; Alzheimer Disease;
Subjects: Science & Engineering > Psychology
Item ID: 3030
Identification Number: 10.4061/2011/383091
Depositing User: Dr. Andrew Coogan
Date Deposited: 26 Jan 2012 15:53
Journal or Publication Title: Journal of Aging Research
Publisher: SAGE-Hindawi Access to Research
Refereed: Yes
URI:

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