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The Immune Response to Parvovirus B19 Exposure in previously Seronegative and Seropositive Individuals

Doyle, Sean and Corcoran, Amanda (2006) The Immune Response to Parvovirus B19 Exposure in previously Seronegative and Seropositive Individuals. The Journal of Infectious Diseases, 194. pp. 154-158.

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Abstract

Little information is available on the immune response to parvovirus B19 after the administration of contaminated blood products. In the present study, we found that levels of B19 IgG in B19-seropositive recipients protect against reinfection and, after transfusion with pooled plasma containing B19 DNA ( IU/mL), increase from 1.6108 19–39 IU/mL to 50–100 IU/mL. We found that, in the presence of 1.6–2.2 108 IU of B19 DNA/mL in B19-seronegative recipients, a pooled-plasma B19 IgG level of 59.5 IU/mL is insufficient to prevent B19 transmission and subsequent seroconversion. These data should lead to improvements in the assessment of blood-product safety.

Item Type: Article
Keywords: Parvovirus B19
Subjects: Science & Engineering > Biology
Item ID: 352
Depositing User: Dr. Sean Doyle
Date Deposited: 26 Jul 2006
Journal or Publication Title: The Journal of Infectious Diseases
Publisher: University of Chicago Press
Refereed: Yes
URI:

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