Mangourova, Violeta and Ringwood, John and Van Vliet, Bruce
Graphical simulation environments for modelling and
simulation of integrative physiology.
Computer Methods and Programs in Biomedicine, 102.
Guyton’s original integrative physiology model was a milestone in integrative physiology,
combining significant physiological knowledge with an engineering perspective to develop
a computational diagrammatic model. It is still used in research and teaching, with a
small number of variants on the model also in circulation. However, though new research
has added significantly to the knowledge represented by Guyton’s model, and significant
advances have been made in computing and simulation software, an accepted common
platform to integrate this new knowledge has not emerged. This paper discusses the issues
in the selection of a suitable platform, together with a number of current possibilities, and
suggests a graphical computing environment for modelling and simulation. Byway of example,
a validated version of Guyton’s 1992 model, implemented in the ubiquitous Simulink
environment, is presented which provides a hierarchical representation amenable to extension
and suitable for teaching and research uses. It is designed to appeal to the biomedical
engineer and physiologist alike.
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Professor John Ringwood
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