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On-line estimation in a distributed parameter bioreactor: Application to the Gluconic Acid production

García, Míriam R. and Vilas, Carlos and Balsa-Canto, Eva and Lyubenova, Velislava N. and Ignatova, Maya N. and Alonso, Antonio A. (2011) On-line estimation in a distributed parameter bioreactor: Application to the Gluconic Acid production. Computers & Chemical Engineering, 35 (1). ISSN 0098-1354

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Abstract

This work presents a methodology which exploits the underlying biochemical structure of bioprocesses to estimate concentrations in aerobic fermenters from oxygen measurements. Although a number of estimators have been proposed over the years in the literature, the methodology proposed in this work is able to operate in transient conditions while does not require the knowledge of the growth kinetics. In addition, it can be also applied to fermenters where the spatial distribution of the concentrations is relevant. In this case, we propose a systematic approach to optimally locate the sensors based on the use of reduced order models. This method allows the reconstruction of the oxygen concentrations from a limited number of sensors. Finally, the methodology proposed will be illustrated on a horizontal tubular reactor for the production of gluconic acid by free-growth of Aspergillus niger.

Item Type: Article
Additional Information: Preprint version of original published article. The definitive version of this article is available from http://www.sciencedirect.com/ at DOI: http://dx.doi.org/10.1016/j.compchemeng.2010.05.005
Keywords: On-line indirect estimation; Aerobic Fermentation; Tubular (Bio)Reactors; Optimal sensor location;
Subjects: Science & Engineering > Hamilton Institute
Item ID: 3625
Depositing User: Miriam Garcia
Date Deposited: 01 May 2012 15:29
Journal or Publication Title: Computers & Chemical Engineering
Publisher: Elsevier
Refereed: No
URI:

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