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Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle Aging

Staunton, Lisa and O’Connell, Kathleen and Ohlendieck, Kay (2011) Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle Aging. Journal of Aging Research (908035). pp. 1-9. ISSN 2090-2204

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Abstract

Mitochondria are of central importance for energy generation in skeletal muscles. Expression changes or functional alterations in mitochondrial enzymes play a key role during myogenesis, fibre maturation, and various neuromuscular pathologies, as well as natural fibre aging.Mass spectrometry-based proteomics suggests itself as a convenient large-scale and high-throughput approach to catalogue the mitochondrial protein complement and determine global changes during health and disease. This paper gives a brief overview of the relatively new field of mitochondrial proteomics and discusses the findings from recent proteomic surveys of mitochondrial elements in aged skeletal muscles. Changes in the abundance, biochemical activity, subcellular localization, and/or posttranslationalmodifications in key mitochondrial enzymes might be useful as novel biomarkers of aging. In the long term, this may advance diagnostic procedures, improve the monitoring of disease progression, help in the testing of side effects due to new drug regimes, and enhance our molecular understanding of age-related muscle degeneration.

Item Type: Article
Additional Information: Copyright © 2011 Lisa Staunton et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The original, definitive version of the article is available in the Journal of Aging Research, 2011, article ID 908035: doi:10.4061/2011/908035 . Research in the author’s laboratory was supported by grants from Science Foundation Ireland, the European Commission, the Irish Health Research Board, the Higher Education Authority, and Muscular Dystrophy Ireland.
Keywords: Proteomic Profiling; Mitochondrial Enzymes; Skeletal Muscle Aging; myogenesis; fibre maturation; neuromuscular pathologies;
Subjects: Science & Engineering > Biology
Item ID: 3777
Depositing User: Prof. Kay Ohlendieck
Date Deposited: 03 Jul 2012 16:04
Journal or Publication Title: Journal of Aging Research
Publisher: SAGE-Hindawi Access to Research
Refereed: Yes
URI:

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