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A 5-component mathematical model for salt-induced hypertension in Dahl-S and Dahl-R rats

McLoone, Violeta and Ringwood, John and Van Vliet, Bruce (2011) A 5-component mathematical model for salt-induced hypertension in Dahl-S and Dahl-R rats. Computer Methods and Programs in Biomedicine, 101. pp. 220-229. ISSN 0169-2607

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Abstract

Salt-induced hypertension has been demonstrated in a variety of species including rats, monkeys, chimpanzees and humans. Until recently, the multiple phases of this blood pressure increase due to high salt intake had not been closely studied. This work builds upon a recent study, which developed a grey-boxmulti-component model of salt-induced hypertension in the Dahl-S rat. The previous 3-component model has been extended here to include additional model dynamics to improve the model fit and add new important elements to the model response. The model was optimised using numerical techniques with experimental data from 4 different protocols with Dahl-S, Dahl-R and FF2 hybrid rats. Results show a marked improvement over the previous model and confirm the merit of the 5-component model structure. A comparison between the model dynamics for different rat strains has also been included

Item Type: Article
Keywords: Hypertension; Mathematical model; Salt intake; Multiple components; Dahl-S; Dahl-R;
Subjects: Science & Engineering > Electronic Engineering
Item ID: 3862
Depositing User: Professor John Ringwood
Date Deposited: 14 Sep 2012 15:05
Journal or Publication Title: Computer Methods and Programs in Biomedicine
Publisher: Elsevier
Refereed: Yes
URI:

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