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Effect of N-chorotaurine on Aspergillus, with particular reference to destruction of secreted gliotoxin

Reeves, Emer and Nagl, Markus and O'Keeffe, Joseph and Kelly, Judy and Kavanagh, Kevin (2006) Effect of N-chorotaurine on Aspergillus, with particular reference to destruction of secreted gliotoxin. Journal of Medical Microbiology, 55. pp. 913-918.

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Abstract

The fungistatic and fungicidal activity of N-chlorotaurine (NCT), a long-lived oxidant produced by stimulated neutrophils, was investigated. Physiological concentrations (75–100 µM) of NCT showed clear fungicidal activity against a range of Aspergillus isolates. Moreover, killing by NCT was significantly increased in the presence of ammonium chloride, explained by the formation of monochloramine by halogenation of ammonium. One clinical isolate of Aspergillus fumigatus was characterized for the production of the immunosuppressive agent gliotoxin, and NCT was shown to cause destruction of gliotoxin, possibly via reduction of the disulphide bridge. Because of its endogenous nature and its high antifungal activity, NCT appears to be a good choice for topical treatment of Aspergillus infections, and the results of this study further substantiate its therapeutic efficacy.

Item Type: Article
Keywords: N-chlorotaurine; Aspergillus; Gliotoxin;
Subjects: Science & Engineering > Biology
Item ID: 905
Depositing User: Dr. Kevin Kavanagh
Date Deposited: 21 Feb 2008
Journal or Publication Title: Journal of Medical Microbiology
Publisher: Churchill Livingstone
Refereed: Yes
URI:

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