Article

Downes, Shane G., Owens, Rebecca A., Walshe, Kieran, Fitzpatrick, David A., Dorey, Amber, Jones, Gary W. and Doyle, Sean (2023) Gliotoxin-mediated bacterial growth inhibition is caused by specific metal ion depletion. Scientific Reports, 13 (1). ISSN 2045-2322

Doyle, Sean, Cuskelly, Daragh D., Conlon, Niall, Fitzpatrick, David A., Gilmartin, Ciara B., Dix, Sophia H. and Jones, Gary W. (2022) A Single Aspergillus fumigatus Gene Enables Ergothioneine Biosynthesis and Secretion by Saccharomyces cerevisiae. International Journal of Molecular Sciences, 23 (18). p. 10832. ISSN 1422-0067

Traynor, Aimee M., Owens, Rebecca A., Coughlin, Claudia M., Holton, Maeve C., Jones, Gary W., Calera, José A. and Doyle, Sean (2021) At the metal–metabolite interface in Aspergillus fumigatus: towards untangling the intersecting roles of zinc and gliotoxin. Microbiology, 167 (11). ISSN 1350-0872

Traynor, Aimee M., Owens, Rebecca A., Coughlin, Claudia M., Holton, Maeve C., Jones, Gary W., Calera, José A. and Doyle, Sean (2021) At the metal–metabolite interface in Aspergillus fumigatus: towards untangling the intersecting roles of zinc and gliotoxin. Microbiology, 167 (11). ISSN 1350-0872

Xu, Linan, Zhang, Hong, Cuskelly, Daragh D., Doyle, Sean, Perrett, Sarah and Jones, Gary W. (2021) Mutational analysis of the Hsp70 substrate‐binding domain: Correlating molecular‐level changes with in vivo function. Molecular Microbiology, 115 (6). pp. 1262-1276. ISSN 0950-382X

Xu, Linan, Nitika, Hasin, Naushaba, Cuskelly, Daragh, Wolfgeher, Donald, Doyle, Sean, Moynagh, Paul N., Perrett, Sarah, Jones, Gary W. and Truman, Andrew W. (2019) Rapid deacetylation of yeast Hsp70 mediates the cellular response to heat stress. Scientific Reports, 9 (16260). ISSN 2045-2322

Doyle, Sean, Jones, Gary W. and Dolan, Stephen K. (2018) Dysregulated gliotoxin biosynthesis attenuates the production of unrelated biosynthetic gene cluster-encoded metabolites in Aspergillus fumigatus. Fungal Biology, 122. pp. 214-221. ISSN 1878-6146

Saleh, Aliabbas A., Jones, Gary W., Tinley, Frances C., Delaney, Stephen F., Alabaddi, Sahar H., Fenlon, Keith, Doyle, Sean and Owens, Rebecca A. (2018) Systems impact of zinc chelation by the epipolythiodioxopiperazine dithiol gliotoxin in Aspergillus fumigatus: a new direction in natural product functionality. Metallomics, 10. pp. 854-866. ISSN 1756-591X

Manfiolli, Adriana Oliveira, Alves de Castro, Patricia, Fernanda dos Reis, Thaila, Dolan, Stephen K., Doyle, John, Jones, Gary W., Riano-Pachon, Diego Mauricio, Ulas, Mevlut, Noble, Luke M., Mattern, Derek J., Brakhage, Axel A., Valiante, Vito, Silva-Rocha, Rafael, Bayram, Ozgur and Goldman, Gustavo H. (2017) Aspergillus fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence. Cellular Microbiology, 19 (e12770). ISSN 1462-5822

Dolan, Stephen K., Bock, Tobias, Hering, Vanessa, Owens, Rebecca A., Jones, Gary W., Blankenfeldt, Wulf and Doyle, Sean (2017) Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus. Open Biology, 7 (2). ISSN 2046-2441

Alves de Castro, Patricia, dos Reis, Thaila Fernanda, Dolan, Stephen K., Manfiolli, Adriana Oliveira, Brown, Neil Andrew, Jones, Gary W., Doyle, Sean, Riaño‐Pachón, Diego M., Squina, Fabio M., Caldana, Camila, Singh, Ashutosh, Del Poeta, Maurizio, Hagiwara, Daisuke, Silva-Rocha, Rafael and Goldman, Gustavo H. (2016) The Aspergillus fumigatus SchASCH9 kinase modulates SakAHOG1 MAP kinase activity and it is essential for virulence. Molecular Microbiology, 102 (4). pp. 642-671. ISSN 1365-2958

Sheridan, Kevin J., Lechner, Beatrix Elizabeth, O'Keeffe, Grainne, Keller, Markus A., Werner, Ernst R., Lindner, Herbert, Jones, Gary W., Haas, Hubertus and Doyle, Sean (2016) Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus. Scientific Reports, 6 (35306). ISSN 2045-2322

Manzanares-Miralles, Lara, Bayram, Ozgur, Sarikaya-Bayram, Ozlem, Smith, Elizabeth B., Dolan, Stephen K., Jones, Gary W. and Doyle, Sean (2016) Quantitative proteomics reveals the mechanism and consequence of gliotoxin-mediated dysregulation of the methionine cycle in Aspergillus niger. Journal of Proteomics, 131. pp. 149-162. ISSN 1874-3919

Smith, Elizabeth B., Dolan, Stephen K., Fitzpatrick, David A., Doyle, Sean and Jones, Gary W. (2016) Towards understanding the gliotoxin detoxification mechanism: in vivo thiomethylation protects yeast from gliotoxin cytotoxicity. Microbial Cell, 3 (3). pp. 120-125. ISSN 2311-2638

Ade, P.A.R., Aghanim, N., Armitage-Caplan, C., Arnaud, Martha B., Ashdown, M., Atrio-Barandela, F., Aumont, J., Aussel, H., Baccigalupi, C., Banday, A.J., Barreiro, R.B., Barrena, R., Bartelmann, M., Bartlett, J.G., Battaner, E., Benabed, K., Benoit, A., Benoit-Lévy, A., Bernard, J.-P., Bersanelli, M., Bielewicz, P., Bikmaev, I., Bobin, J., Bock, J.J., Böhringer, H., Bonaldi, A., Bond, J.R., Borrill, J., Bouchet, F.R., Bridges, M., Bucher, M., Burenin, R., Burigana, C., Butler, R.C., Cardoso, J.-F., Carvalho, P., Catalano, A., Challinor, A., Chamballu, A., Chary, R.-R., Chen, X., Chiang, H.C., Chiang, L.-Y., Chon, G., Christensen, P.R., Churazov, E., Church, S., Clements, D.L., Colombi, S., Colombo, L.P.L., Comis, B., Couchot, F., Coulais, A., Crill, B.P., Curto, A., Cuttaia, F., Da Silva, A., Dahle, H., Danese, L., Davies, R.D., Davis, R.J., De Bernardis, P., de Rosa, A., de Zotti, G., Delabrouille, J., Delouis, J.-M., Démoclès, J., Desert, F.-X., Dickinson, C., Diego, J.M., Dolag, K., Dole, H., Donzelli, S., Dore, O., Douspis, M., Dupac, X., Efstathiou, G., Enßlin, T.A., Eriksen, H.K., Feroz, F., Ferragamo, A., Finelli, F., Flores-Cacho, I., Forni, O., Frailis, M., Franceschi, E., Fromenteau, S., Galeotta, S., Ganga, K., Genova-Santos, R.T., Giard, M., Giardino, G., Gilfanov, M., Giraud-Héraud, Y., Gonzalez-Nuevo, J., Gorski, K.M., Grainge, K.J.B., Gratton, S., Gregorio, A., Groeneboom, N.E., Gruppuso, A., Hansen, F.K., Hanson, D., Harrison, D., Hempel, A., Henrot-Versille, S., Hernandez-Monteagudo, C., Herranz, D., Hildebrandt, S.R., Hivon, E., Hobson, M., Holmes, W.A., Hornstrup, A., Hovest, W., Huffenberger, K.M., Hurier, G., Hurley-Walker, N., Jaffe, A.H., Jaffe, T.R., Jones, Gary W., Juvela, M., Keihanen, E., Keskitalo, R., Khamitov, I., Kisner, T.S., Kneissl, R., Knoche, J., Knox, L., Kunz, M., Kurki-Suonio, H., Lagache, G., Lahteenmaki, A., Lamarre, J.-M., Lasenby, A., Laureijs, R.J., Lawrence, C.R., Leahy, J.P., Leonardi, R., Leon-Tavares, J., Lesgourgues, J., Li, C., Liddle, A., Liguori, M., Lilje, P.B., Linden-Vornle, M., Lopez-Caniego, M., Lubin, P.M., Macias-Perez, J.F., MacTavish, C.J., Maffei, B., Maino, D., Mandolesi, N., Maris, M., Marshall, D.J., Martin, P.G., Martinez-Gonzalez, E., Masi, S., Massardi, M., Matarrese, S., Matthai, F., Mazzotta, P., Mei, S., Meinhold, P.R., Melchiorri, A., Melin, J.-B., Mendes, L., Mennella, A., Migliaccio, M., Mikkelsen, K., Mitra, S., Miville-Deschenes, M.-A., Moneti, A., Montier, L., Morgante, G., Mortlock, D., Munshi, D., Murphy, J.Anthony, Naselsky, P., Nastasi, A., Nati, F., Natoli, P., Nesvadba, N.P.H., Netterfield, C.B., Norgaard-Nielsen, H.U., Noviello, F., Novikov, D., Novikov, I., O'Dwyer, I.J., Olamaie, M., Osborne, S., Oxborrow, C.A., Paci, F., Pagano, L., Pajot, F., Paoletti, D., Pasian, F., Patanchon, G., Pearson, T.J., Perdereau, O., Perotto, L., Perrott, Y.C., Perrotta, F., Piacentini, F., Piat, M., Pierpaoli, E., Pietrobon, D., Plaszczynski, S., Pointecouteau, E., Polenta, G., Ponthieu, N., Popa, L., Poutanen, T., Pratt, G.W., Prezeau, G., Prunet, S., Puget, J.-L., Rachen, J.P., Reach, W.T., Rebolo, R., Reinecke, M., Remazeilles, M., Renault, C., Ricciardi, S., Riller, T., Ristorcelli, I., Rocha, G., Rosset, C., Roudier, G., Rowan-Robinson, M., Rubino-Martin, J.A., Rumsey, C., Rusholme, B., Sandri, M., Santos, D., Saunders, R.D.E., Savini, G., Schammel, M.P., Scott, D., Seiffert, M.D., Shellard, E.P.S., Shimwell, T.W., Spencer, L., Starck, J.-L., Stolyarov, V., Stompor, R., Streblyanska, A., Sudiwala, R., Sunyaev, R., Sureau, F., Sutton, D., Suur-Uski, A.-S., Sygnet, J.-F., Tauber, J.A., Tavagnacco, D., Terenzi, L., Toffolatti, L., Tomasi, M., Tramonte, D., Tristram, M., Tucci, M., Tuovinen, J., Turler, M., Umana, G., Valenziano, L., Valiviita, J., Van Tent, B., Vibert, L., Vielva, P., Villa, F., Vittorio, N., Wade, L.A., Wandelt, B.D., White, M., White, S.D.M., Yvon, D., Zacchei, A. and Zonca, A. (2015) Planck 2013 results. XXXII. The updated Planck catalogue of Sunyaev-Zeldovich sources. Astronomy & Astrophysics, 581 (A141). ISSN 0004-6361

Dolan, Stephen K., O'Keefe, Grainne, Jones, Gary W. and Doyle, Sean (2015) Resistance is not futile: gliotoxin biosynthesis, functionality and utility. Trends in Microbiology, 23 (7). pp. 419-428. ISSN 0966-842X

Winkelstroter, Lizziane K., Dolan, Stephen K., Fernanda dos Reis, Thaila, Pedro Bom, Vinicius Leite, Alves de Castro, Patricia, Hagiwara, Daisuke, Alowni, Raneem, Jones, Gary W., Doyle, Sean, Brown, Neil Andrew and Goldman, Gustavo H. (2015) Systematic Global Analysis of Genes Encoding Protein Phosphatases in Aspergillus fumigatus. G3 : Genes, Genomes, Genetics, 5. pp. 1525-1539. ISSN 2160-1836

Hasin, Naushaba, Cusack, Sarah, Ali, Shahin S., Fitzpatrick, David A. and Jones, Gary W. (2014) Global transcript and phenotypic analysis of yeast cells expressing Ssa1, Ssa2, Ssa3 or Ssa4 as sole source of cytosolic Hsp70-Ssa chaperone activity. BMC Genomics, 15 (194). pp. 1-12. ISSN 1471-2164

He, Jianwei, Wang, Yu, Chang, Alan K., Xu, Linan, Wang, Na, Chong, Xiaoying, Li, Hui, Zhang, Bing, Jones, Gary W. and Song, Youtao (2014) Myricetin Prevents Fibrillogenesis of Hen Egg White Lysozyme. Journal of Agricultural and Food Chemistry, 62. pp. 9442-9449. ISSN 0021-8561

Keane, Orla M., Toft, Christina, Carretero-Paulet, Lorenzo, Jones, Gary W. and Fares, Mario A. (2014) Preservation of Genetic and Regulatory Robustness in Ancient Gene Duplicates of Saccharomyces cerevisiae. Genome Research, 14. pp. 1-29. ISSN 1088-9051

Owens, Rebecca A., Hammel, Stephen, Sheridan, Kevin J., Jones, Gary W. and Doyle, Sean (2014) A Proteomic Approach to Investigating Gene Cluster Expression and Secondary Metabolite Functionality in Aspergillus fumigatus. PLoS ONE, 9 (9). e106942. ISSN 1932-6203

O’Keeffe, Grainne, Hammel, Stephen, Owens, Rebecca A., Keane, Thomas M., Fitzpatrick, David A., Jones, Gary W. and Doyle, Sean (2014) RNA-seq reveals the pan-transcriptomic impact of attenuating the gliotoxin self-protection mechanism in Aspergillus fumigatus. BMC Genomics, 15 (894). pp. 1-26. ISSN 1471-2164

Dolan, Stephen K., Owens, Rebecca A., O'Keefe, Grainne, Hammel, Stephen, Fitzpatrick, David A., Jones, Gary W. and Doyle, Sean (2014) Regulation of Nonribosomal Peptide Synthesis: bis-Thiomethylation Attenuates Gliotoxin Biosynthesis in Aspergillus fumigatus. Chemistry and Biology, 21 (8). pp. 999-2012. ISSN 1074-5521

Jones, Gary W., Doyle, Sean and Fitzpatrick, David A. (2014) The evolutionary history of the genes involved in the biosynthesis of the antioxidant ergothioneine. Gene, 549 (1). pp. 161-170. ISSN 0378-1119

Moran, Ciara, Kinsella, Gemma K., Zhang, Zai-Rong, Perrett, Sarah and Jones, Gary W. (2013) Mutational Analysis of Sse1 (Hsp110) Suggests an Integral Role for this Chaperone in Yeast Prion Propagation In Vivo. G3. ISSN 2160-1836

Fares, Mario A., Keane, Orla M., Toft, Christina, Carretero-Paulet, Lorenzo and Jones, Gary W. (2013) The Roles of Whole-Genome and Small-Scale Duplications in the Functional Specialization of Saccharomyces cerevisiae Genes. PLos Genetics, 9 (1). e1003176. ISSN 1553-7390

Xu, Li-Qiong, Wu, Si, Buell, Alexander K., Cohen, Samuel I.A., Chen, Li-Jun, Hu, Wan-Hui, Cusack, Sarah, Itzhaki, Laura S., Zhang, Hong, Knowles, Tuomas P.J., Dobson, Christopher M., Welland, Mark E., Jones, Gary W. and Perrett, Sarah (2013) Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2. Philosophical Transactions of the Royal Society B, 368 (1617). p. 20110410. ISSN 0962-8436

Xu, Linan, Hasin, Naushaba, Shen, Manli, He, Jianwei, Xue, Youlin, Zhou, Xiaohong, Perrett, Sarah, Song, Youtao and Jones, Gary W. (2013) Using Steered Molecular Dynamics to Predict and Assess Hsp70 Substrate-Binding Domain Mutants that Alter Prion Propagation. PLoS Computational Biology, 9 (1). ISSN 1553-734X

Truman, Andrew W., Kristjansdottir, Kolbrun, Wolfgeher, Donald, Hasin, Naushaba, Polier, Sigrun, Zhang, Hong, Perrett, Sarah, Prodromou, Chrisostomos, Jones, Gary W. and Kron, Stephen J. (2012) CDK-Dependent Hsp70 Phosphorylation Controls G1 Cyclin Abundance and Cell-Cycle Progression. Cell, 151 (6). pp. 1308-1318. ISSN 0092-8674

Carberry, Stephen, Molloy, Emer, Hammel, Stephen, O'Keefe, Grainne, Jones, Gary W., Kavanagh, Kevin and Doyle, Sean (2012) Gliotoxin effects on fungal growth: Mechanisms and exploitation. Fungal Genetics and Biology, 49 (4). pp. 302-312. ISSN 1087-1845

O'Hanlon, Karen, Margison, Geoffrey P., Hatch, Amy, Fitzpatrick, David A., Owens, Rebecca A., Doyle, Sean and Jones, Gary W. (2012) Molecular characterization of an adaptive response to alkylating agents in the opportunistic pathogen Aspergillus fumigatus. Nucleic Acids Research, 40 (16). pp. 7806-7820. ISSN 0305-1048

Gallagher, Lorna, Owens, Rebecca A., Dolan, Stephen K., O'Keefe, Grainne, Schrettl, Markus, Kavanagh, Kevin, Jones, Gary W. and Doyle, Sean (2012) The Aspergillus fumigatus Protein GliK Protects against Oxidative Stress and Is Essential for Gliotoxin Biosynthesis. Eukaryotic Cell, 11 (10). pp. 1226-1238. ISSN 1535-9778

Fitzpatrick, David A., O'Brien, Jennifer, Moran, Ciara, Hasin, Naushaba, Kenny, Elaine, Cormican, Paul, Gates, Amy, Morris, Derek W. and Jones, Gary W. (2011) Assessment of Inactivating Stop Codon Mutations in Forty Saccharomyces cerevisiae Strains: Implications for [PSI+] Prion-Mediated Phenotypes. PLoS ONE, 6 (12). e28684. ISSN 1932-6203

Medina, Edgar M., Jones, Gary W. and Fitzpatrick, David A. (2011) Reconstructing the Fungal Tree of Life Using Phylogenomics and a Preliminary Investigation of the Distribution of Yeast Prion-Like Proteins in the Fungal Kingdom. Journal of Molecular Evolution, 73 (3-4). pp. 116-133. ISSN 0022-2844

Schrettl, Markus, Carberry, Stephen, Kavanagh, Kevin, Haas, Hubertus, Jones, Gary W., O'Brien, Jennifer, Nolan, Aine, Stephens, John C., Fenelon, Orla and Doyle, Sean (2010) Self-Protection against Gliotoxin—A Component of the Gliotoxin Biosynthetic Cluster, GliT, Completely Protects Aspergillus fumigatus Against Exogenous Gliotoxin. PLOS Pathogens, 6 (6). ISSN 1553-7366

Jones, Gary W. and Tuite, M.F. (2005) Chaperoning prions: the cellular machinery for propagating an infectious protein? BioEssays, 27. pp. 823-832.